Z77 Extreme3 / Intel USB 3.0 driver ver:1.0.5.235

That is just Windows warning you that you are about to run an executable file that was downloaded from the internet. It is a generic warning that can sometimes be a pain. In this instance it seems to be warning about one of the driver's background components. Usually unchecking the box "Always ask..." then hitting run should stop it occurring again but sometimes windows does not save the setting. If unchecking the box does not work then you will need to manually add the "iusb3mon.exe" file to the exception list (essentially what unchecking the box should do). Personally I always turn the security down to the lowest value and avoid all this. If you frequently get infected by viruses/spyware/malware however I would not recommend turning off/lowering security.