Running 2 nvidia Series cards

#1 Yes. Both GPU should work if you move the NVMe SSD from M2_1 slot -> M2_2 slot. It's fairly simple. PCIe slot #4 will be disabled if you put NVMe SSD into M2_1 slot. So don't put anything into M2_1 slot.

You can use M2_2 slot just fine.

Not sure what you mean by #2. You can use SATA (2.5-inch or m.2) drives without affecting PCIe slots. Note M2_1 slot doesn't appear to support SATA drive anyway.

And the manual says M2_2 and SATA #3 and #4 share lanes, so you'll have to be careful about that.

I assume you have an NVMe m.2 card occupying the M2_1 slot?
Spec says, "If M2_1 is occupied, PCIE4 will be disabled."

AM4 Ryzen CPUs have at most 24 PCIe lanes.
4 lanes are connected to the chipset (B450).
16 lanes are connected to PCIe Slot #2.
4 lanes are connected to PCIe Slot #4 & M2_1 Slot. Only one of them will work.

You'll have to use M2_2 Slot, which is going through the chipset and narrower (2 lanes). If you need two NVMe SSDs, you'll have to get an adapter and put it on one of the other PCIe slots (PCIe Slot #1 for example). That one will be even slower, as it's going through the chipset and is PCIe Gen2 and just 1 lane.

I guess another option is to get a splitter and enable PCIe lane bifurcation, and turn the PCIe Slot #2 into two 8-lane slots. That'd be all kinds of mess to make it fit, though. And I don't even know if the BIOS of that board supports bifurcation.


Edited by eccential - 09 Sep 2023 at 5:36pm