USB mouse and keyboard working in BIOS, not in WIN

elserge82 wrote: Yes. The ones that are not working 2 front usb 2.0 (port 1) , 2 front usb 3.0 (port 2) and the second  rear raw 2  usb 3.0. port 2 2.0 and 1 3.0 are not connected

Ok, so out of the 4 USB connectors on the motherboard you are using two (one of each type). Have you tried switching to the other available connectors? Another thing you could try is only using one of the USB 2.0 connectors from the motherboard and seeing if that makes a difference.

If none of the rear USB 3.0 ports are working, have you tried unplugging your keyboard and your mouse after Windows have booted and then plugging them back in? My old 970M Pro3 would occasionally not recognize my WLAN adapter or my mouse (one or the other) after startup and this would fix the issue.